InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMEM48

Summary

InnateDB Protein

IDBP-98762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMEM48

Protein Name

transmembrane protein 48

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360483

InnateDB Gene

IDBG-98760 (TMEM48)

Protein Structure

UniProt Annotation

Function

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269PubMed:16600873, ECO:0000269PubMed:16702233}.

Subcellular Localization

Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0015031	protein transport
GO:0031081	nuclear pore distribution
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly