InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K4

Summary

InnateDB Protein

IDBP-98780.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K4

Protein Name

mitogen-activated protein kinase kinase kinase 4

Synonyms

MAPKKK4; MEKK 4; MEKK4; MTK1; PRO0412;

Species

Homo sapiens

Ensembl Protein

ENSP00000355886

InnateDB Gene

IDBG-98770 (MAP3K4)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269PubMed:12052864, ECO:0000269PubMed:9305639}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269PubMed:9305639}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0010225	response to UV-C
GO:0035556	intracellular signal transduction
GO:0043507	positive regulation of JUN kinase activity
GO:0045087	innate immune response (InnateDB)
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt