InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARK2

Summary

InnateDB Protein

IDBP-98844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARK2

Protein Name

parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Synonyms

AR-JP; LPRS2; PDJ; PRKN;

Species

Homo sapiens

Ensembl Protein

ENSP00000355858

InnateDB Gene

IDBG-98830 (PARK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 456 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	456 [view]
Protein-Protein	453 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR003977 E3 ubiquitin-protein ligase parkin
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF11976

PRINTS

PR01475
PR00348

PIRSF

PIRSF037880

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References