Version 5.4
Homo sapiens Protein: PLEK2
Summary
InnateDB Protein IDBP-9891.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEK2
Protein Name pleckstrin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216446
InnateDB Gene IDBG-9889 (PLEK2)
Protein Structure
UniProt Annotation
Function May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
Subcellular Localization Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031258 lamellipodium membrane
Protein Structure and Domains
PDB ID
InterPro IPR000591 DEP domain
IPR001849 Pleckstrin homology domain
PFAM PF00610
PF00169
PRINTS
PIRSF
SMART SM00049
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYT0
PhosphoSite PhosphoSite-Q9NYT0
TrEMBL
UniProt Splice Variant
Entrez Gene 26499
UniGene Hs.170473
RefSeq NP_057529
HUGO HGNC:19238
OMIM 608007
CCDS CCDS9782
HPRD 12151
IMGT
EMBL AF228603 BC001226 BC008056
GenPept AAF34791 AAH01226 AAH08056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca