InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JUN

Summary

InnateDB Protein

IDBP-99223.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JUN

Protein Name

jun proto-oncogene

Synonyms

AP-1; AP1; c-Jun;

Species

Homo sapiens

Ensembl Protein

ENSP00000360266

InnateDB Gene

IDBG-99221 (JUN)

Protein Structure

UniProt Annotation

Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000269PubMed:10995748, ECO:0000269PubMed:17210646}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 519 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	521 [view]
Protein-Protein	288 [view]
Protein-DNA	227 [view]
Protein-RNA	1 [view]
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0070412	R-SMAD binding
GO:0071837	HMG box domain binding

Biological Process

GO:0001525	angiogenesis
GO:0001774	microglial cell activation
GO:0001836	release of cytochrome c from mitochondria
GO:0001889	liver development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0003151	outflow tract morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007184	SMAD protein import into nucleus
GO:0007568	aging
GO:0007612	learning
GO:0007623	circadian rhythm
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0009987	cellular process
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0030224	monocyte differentiation
GO:0031103	axon regeneration
GO:0031953	negative regulation of protein autophosphorylation
GO:0032321	positive regulation of Rho GTPase activity
GO:0032496	response to lipopolysaccharide
GO:0034097	response to cytokine
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035026	leading edge cell differentiation
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043922	negative regulation by host of viral transcription
GO:0043923	positive regulation by host of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045657	positive regulation of monocyte differentiation
GO:0045740	positive regulation of DNA replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051365	cellular response to potassium ion starvation
GO:0051403	stress-activated MAPK cascade
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0051899	membrane depolarization
GO:0060395	SMAD protein signal transduction
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0000228	nuclear chromosome
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005719	nuclear euchromatin
GO:0005829	cytosol
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

IPR002112 Transcription factor Jun
IPR004827 Basic-leucine zipper domain
IPR005643 Jun-like transcription factor
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716
PF03957

PRINTS

PR00043

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt