InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE4B

Summary

InnateDB Protein

IDBP-99486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4B

Protein Name

phosphodiesterase 4B, cAMP-specific

Synonyms

DPDE4; PDEIVB;

Species

Homo sapiens

Ensembl Protein

ENSP00000332116

InnateDB Gene

IDBG-99484 (PDE4B)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269PubMed:10846163, ECO:0000269PubMed:15003452}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain, heart, lung and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0030552	cAMP binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035690	cellular response to drug
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0071222	cellular response to lipopolysaccharide
GO:0071872	cellular response to epinephrine stimulus
GO:0086004	regulation of cardiac muscle cell contraction
GO:1901841	regulation of high voltage-gated calcium channel activity
GO:1901898	negative regulation of relaxation of cardiac muscle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005891	voltage-gated calcium channel complex
GO:0030018	Z disc
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt