InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GADD45A

Summary

InnateDB Protein

IDBP-99584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45A

Protein Name

growth arrest and DNA-damage-inducible, alpha

Synonyms

DDIT1; GADD45;

Species

Homo sapiens

Ensembl Protein

ENSP00000360024

InnateDB Gene

IDBG-99580 (GADD45A)

Protein Structure

UniProt Annotation

Function

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:7973727}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	139 [view]
Protein-Protein	127 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000185	activation of MAPKKK activity
GO:0006281	DNA repair
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0071260	cellular response to mechanical stimulus
GO:0071479	cellular response to ionizing radiation
GO:1900745	positive regulation of p38MAPK cascade
GO:2000379	positive regulation of reactive oxygen species metabolic process