InnateDB Protein
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IDBP-99587.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GNG12
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Protein Name
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guanine nucleotide binding protein (G protein), gamma 12
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360021
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InnateDB Gene
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IDBG-99585 (GNG12)
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Protein Structure
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Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001770
G-protein, gamma subunit
IPR015898
G-protein gamma-like domain
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PFAM |
PF00631
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PRINTS |
PR00321
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PIRSF |
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SMART |
SM00224
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBI6
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PhosphoSite |
PhosphoSite-Q9UBI6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55970
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UniGene |
Hs.431101
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RefSeq |
NP_061329
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HUGO |
HGNC:19663
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OMIM |
615405
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CCDS |
CCDS30749
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HPRD |
13592
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IMGT |
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EMBL |
AF119663
AF123766
AF188181
AF365871
AF493879
AK293101
AL832431
BC005940
CH471059
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GenPept |
AAF04571
AAF17220
AAH05940
AAK53385
AAM12593
AAP97245
BAF85790
CAH10645
EAX06484
EAX06485
EAX06486
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