InnateDB Protein
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IDBP-99967.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DNASE2B
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Protein Name
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deoxyribonuclease II beta
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359696
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InnateDB Gene
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IDBG-99961 (DNASE2B)
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Protein Structure
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Function |
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269PubMed:11700027, ECO:0000269PubMed:12944971}.
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Subcellular Localization |
Lysosome {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269PubMed:11376952, ECO:0000269PubMed:11700027, ECO:0000269PubMed:12944971}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004531
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deoxyribonuclease II activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004947
Deoxyribonuclease II
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PFAM |
PF03265
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WZ79
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PhosphoSite |
PhosphoSite-Q8WZ79
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58511
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UniGene |
Hs.129142
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RefSeq |
NP_490649
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HUGO |
HGNC:28875
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OMIM |
608057
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CCDS |
CCDS694
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HPRD |
09728
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IMGT |
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EMBL |
AF274571
AF333389
AF334602
AL359273
CH471097
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GenPept |
AAF76893
AAL34448
AAL34449
CAH73126
CAH73127
EAW73238
EAW73239
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