Version 5.4
Homo sapiens Gene: DDAH1
Summary
InnateDB Gene IDBG-100049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDAH1
Gene Name dimethylarginine dimethylaminohydrolase 1
Synonyms DDAH; HEL-S-16
Species Homo sapiens
Ensembl Gene ENSG00000153904
Encoded Proteins
IDBP-100051
dimethylarginine dimethylaminohydrolase 1
IDBP-386340
dimethylarginine dimethylaminohydrolase 1
IDBP-592708
dimethylarginine dimethylaminohydrolase 1
IDBP-592633
dimethylarginine dimethylaminohydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85318481-85578363
Strand Reverse strand
Band p22.3
Transcripts
ENST00000284031 ENSP00000284031
ENST00000426972 ENSP00000411189
ENST00000483110
ENST00000488557
ENST00000498304
ENST00000467530
ENST00000472448
ENST00000467666
ENST00000539042 ENSP00000438604
ENST00000535924 ENSP00000439045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0046872 metal ion binding
Biological Process
GO:0000052 citrulline metabolic process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0007263 nitric oxide mediated signal transduction
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028194
View Gene Order
ENSBTAG00000034776
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713411 Hs.731520
RefSeq NM_001134445 NM_012137 XM_005270706 XM_005270707 XM_005270708 XM_005270709 XM_005270710 XM_006710543 XM_006710544
HUGO
OMIM
CCDS CCDS44170 CCDS705
HPRD 09203
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca