Version 5.4
Homo sapiens Gene: CCBL2
Summary
InnateDB Gene IDBG-100143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCBL2
Gene Name cysteine conjugate-beta lyase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137944
Encoded Proteins
IDBP-100145
cysteine conjugate-beta lyase 2
IDBP-100147
cysteine conjugate-beta lyase 2
IDBP-100149
cysteine conjugate-beta lyase 2
IDBP-100151
cysteine conjugate-beta lyase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:88935773-88992953
Strand Reverse strand
Band p22.2
Transcripts
ENST00000260508 ENSP00000260508
ENST00000370491 ENSP00000359522
ENST00000370486 ENSP00000359517
ENST00000370485 ENSP00000359516
ENST00000446900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0047315 kynurenine-glyoxylate transaminase activity
GO:0047804 cysteine-S-conjugate beta-lyase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006569 tryptophan catabolic process
GO:0009058 biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0070189 kynurenine metabolic process
GO:0097052 L-kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040213
View Gene Order
ENSBTAG00000000505
Not yet available
Pathways
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q6YP21
TrEMBL B4DW13
UniProt Splice Variant
Entrez Gene 56267
UniGene
RefSeq NM_001008661 NM_001008662
HUGO HGNC:33238
OMIM 610656
CCDS CCDS30766 CCDS30767
HPRD 13752
IMGT
EMBL AF091090 AK057176 AK301326 AK315917 AL139416 AL445991 AY028624 BC000819 CH471097 CR450282 CR627392
GenPept AAC72959 AAH00819 AAK26163 BAG51875 BAG62875 BAH14288 CAG29278 CAH10487 CAI21695 CAI21696 CAI41339 CAI41340 CAI41345 EAW73158
RNA Seq Atlas 56267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca