InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GBP2

Summary

InnateDB Gene

IDBG-100168.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GBP2

Gene Name

guanylate binding protein 2, interferon-inducible

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000162645

Encoded Proteins

IDBP-100172

guanylate binding protein 2, interferon-inducible

IDBP-594009

guanylate binding protein 2, interferon-inducible

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21757726

GBP2 localizes to intracellular compartments positive for macroautophagy markers and Immunity-Related GTPases (IRGs) indirectly modulate GBP2 localization. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21757726

[Mus musculus] Gbp2 localizes to intracellular compartments positive for macroautophagy markers and Immunity-Related GTPases (IRGs) indirectly modulate Gbp2 localization.

Entrez Gene

Summary

Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP. [provided by RefSeq, Jul 2008]
This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:89106132-89150456

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000370466	ENSP00000359497
ENST00000464839	ENSP00000434282
ENST00000493802
ENST00000463660

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	41 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000028270

View Gene Order

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_25078

Interferon gamma signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P32456

TrEMBL

Q8TCE5

UniProt Splice Variant

Entrez Gene

2634

UniGene

Hs.386567

RefSeq

NM_004120

HUGO

HGNC:4183

OMIM

600412

CCDS

CCDS719

HPRD

02682

IMGT

EMBL

AC104459 AK314325 AL832451 BC022272 BC073163 CH471097 CR457062 M55543

GenPept

AAA67323 AAH22272 AAH73163 BAG36973 CAD89925 CAG33343 EAW73146

RNA Seq Atlas

2634