InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNAI3

Summary

InnateDB Gene

IDBG-100849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAI3

Gene Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

Synonyms

87U6; ARCND1

Species

Homo sapiens

Ensembl Gene

ENSG00000065135

Encoded Proteins

IDBP-100851

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21209316

GNAI3 is a G protein involved in autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (CCDC88A) and GDI inhibitor (GPSM1). During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.

InnateDB Annotation from Orthologs

Summary

PMID 21209316

[Mus musculus] Gnai3 is a G protein involved in anti-autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (Ccdc88a) and GDI inhibitor (Gpsm1). During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signalling pathways.

Entrez Gene

Summary

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:109548611-109618321

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000369851

ENSP00000358867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0019904	protein domain specific binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0032794	GTPase activating protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006810	transport
GO:0006906	vesicle fusion
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0042588	zymogen granule
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000001

View Gene Order

ENSBTAG00000013016

Not yet available

Pathways

NETPATH

NetPath_23

TSH pathway

REACTOME

REACT_20653

ADP signalling through P2Y purinoceptor 12 pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_15333

Adenylate cyclase inhibitory pathway pathway

REACT_15426

PLC beta mediated events pathway

REACT_15457

G-protein activation pathway

REACT_15295

Opioid Signalling pathway

REACT_25031

GABA B receptor activation pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_25199

GABA receptor activation pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_25330

Activation of GABAB receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_15526

G-protein mediated events pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_25282

Inhibition of adenylate cyclase pathway pathway

REACT_20524

Signal amplification pathway

REACT_604

Hemostasis pathway

KEGG

hsa04540

Gap junction pathway

hsa04360

Axon guidance pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa04730

Long-term depression pathway

hsa04916

Melanogenesis pathway

hsa05012

Parkinson's disease pathway

hsa04062

Chemokine signaling pathway pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa04971

Gastric acid secretion pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

shp2_pathway

SHP2 signaling

cxcr3pathway

CXCR3-mediated signaling events

Cross-References

SwissProt

P08754

TrEMBL

C9J2Z2

UniProt Splice Variant

Entrez Gene

2773

UniGene

Hs.73799 Hs.741171

RefSeq

NM_006496

HUGO

HGNC:4387

OMIM

139370

CCDS

CCDS802

HPRD

IMGT

EMBL

AC004159 AC080066 AF493907 AK312252 BC025285 BT019973 BT019974 CH471122 J03005 J03198 J03238 M20597 M20598 M20599 M20600 M20601 M20602 M20603 M20604 M27543

GenPept

AAA35895 AAA35896 AAA35939 AAA52557 AAA52579 AAH25285 AAM12621 AAV38776 AAV38777 BAG35184 EAW56393

RNA Seq Atlas

2773