Homo sapiens Gene: GNAI3
Summary
InnateDB Gene IDBG-100849.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol GNAI3
Gene Name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Synonyms 87U6; ARCND1;
Species Homo sapiens
Ensembl Gene ENSG00000065135
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Protein Structure
InnateDB Annotation
Summary
GNAI3 is a G protein involved in autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (CCDC88A) and GDI inhibitor (GPSM1). During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Gnai3 is a G protein involved in anti-autophagy signalling pathways and is tightly regulated through its interaction with its GEF activator (Ccdc88a) and GDI inhibitor (Gpsm1). During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signalling pathways.
Entrez Gene
Summary Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:110091233-110136975
Strand Forward strand
Band p13.3
Transcripts
ENST00000369851 ENSP00000358867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 78 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006810 transport
GO:0006906 vesicle fusion
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0045087 innate immune response (InnateDB)
GO:0050805 negative regulation of synaptic transmission
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030496 midbody
GO:0031234 extrinsic to internal side of plasma membrane
GO:0042588 zymogen granule
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
ADP signalling through P2Y purinoceptor 12 pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
G-protein activation pathway
KEGG
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Gap junction pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Long-term depression pathway
Melanogenesis pathway
Toxoplasmosis pathway
Gastric acid secretion pathway
Chagas disease (American trypanosomiasis) pathway
INOH
PID BIOCARTA
PID NCI
SHP2 signaling
EGF receptor (ErbB1) signaling pathway
CXCR3-mediated signaling events
Cross-References
SwissProt P08754
TrEMBL C9J2Z2 Q5TZX1
UniProt Splice Variant
Entrez Gene 2773
UniGene Hs.73799 Hs.741171
RefSeq NM_006496
HUGO 4387
OMIM 139370
CCDS CCDS802
HPRD 00765
IMGT
EMBL AC004159 AC080066 AF493907 AK312252 AL355310 BC025285 BT019973 BT019974 CH471122 J03005 J03198 J03238 M20597 M20598 M20599 M20600 M20601 M20602 M20603 M20604 M27543
GenPept AAA35895 AAA35896 AAA35939 AAA52557 AAA52579 AAH25285 AAM12621 AAV38776 AAV38777 BAG35184 CAI19303 EAW56393
ImmGen GNAI3 (murine)
RNA Seq Atlas 2773