Version 5.4
Homo sapiens Gene: CD58
Summary
InnateDB Gene IDBG-101394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD58
Gene Name CD58 molecule
Synonyms ag3; LFA-3; LFA3
Species Homo sapiens
Ensembl Gene ENSG00000116815
Encoded Proteins
IDBP-101396
CD58 molecule
IDBP-101404
CD58 molecule
IDBP-387885
CD58 molecule
IDBP-596281
CD58 molecule
IDBP-597672
CD58 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:116514535-116571039
Strand Reverse strand
Band p13.1
Transcripts
ENST00000369489 ENSP00000358501
ENST00000369487 ENSP00000358499
ENST00000457047 ENSP00000409080
ENST00000464088 ENSP00000432773
ENST00000526981 ENSP00000433648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0016337 single organismal cell-cell adhesion
GO:0034113 heterotypic cell-cell adhesion
GO:0050900 leukocyte migration
GO:0071346 cellular response to interferon-gamma
GO:0071356 cellular response to tumor necrosis factor
GO:2000484 positive regulation of interleukin-8 secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt P19256
TrEMBL
UniProt Splice Variant
Entrez Gene 965
UniGene Hs.34341
RefSeq NM_001144822 NM_001779
HUGO HGNC:1688
OMIM 153420
CCDS CCDS44199 CCDS888
HPRD 01081
IMGT
EMBL AK291980 AL355794 AL390066 BT019816 BT019817 CH471122 CR456939 X06296 Y00636 Y14780 Y14781 Y14782 Y14783 Y14784 Y14785
GenPept AAV38619 AAV38620 BAF84669 CAA29622 CAA68668 CAA75083 CAA75084 CAG33220 CAI19099 CAI22762 EAW56652 EAW56653
RNA Seq Atlas 965

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca