Version 5.4
| Homo sapiens Gene: MLST8 | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-10142.6 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | MLST8 | ||||||||||||||||||||||||||
| Gene Name | MTOR associated protein, LST8 homolog (S. cerevisiae) | ||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000167965 | ||||||||||||||||||||||||||
| Encoded Proteins |
MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR associated protein, LST8 homolog (S. cerevisiae)
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| Protein Structure | |||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||
| Summary |
MLST8 regulates TNF-alpha-induced NF-kappaB signalling by directly inhibiting the activation of IkappaB kinase.
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| Entrez Gene | |||||||||||||||||||||||||||
| Summary | Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs. | ||||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 16:2204248-2209416 | ||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||
| Band | p13.3 | ||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
PI3K/AKT activation pathway
Release of eIF4E pathway
S6K1-mediated signalling pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
VEGFR2 mediated vascular permeability pathway
mTORC1-mediated signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
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| KEGG |
mTOR signaling pathway pathway
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| INOH |
Insulin receptor signaling pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
ErbB1 downstream signaling
mTOR signaling pathway
LKB1 signaling events
CXCR3-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||
| UniGene | Hs.29203 Hs.618680 Hs.691112 | ||||||||||||||||||||||||||
| RefSeq | NM_001199173 NM_001199174 NM_001199175 NM_022372 XM_005255475 XM_005255476 XM_005255478 XM_005255479 XM_005255480 | ||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | CCDS10462 CCDS58409 | ||||||||||||||||||||||||||
| HPRD | 17031 | ||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||