Version 5.4
Homo sapiens Gene: TRIM45
Summary
InnateDB Gene IDBG-101433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM45
Gene Name tripartite motif containing 45
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134253
Encoded Proteins
IDBP-101435
tripartite motif containing 45
IDBP-101437
tripartite motif containing 45
IDBP-101439
tripartite motif containing 45
IDBP-586195
tripartite motif containing 45
IDBP-811918
tripartite motif containing 45
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
TRIM45 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:117111060-117122587
Strand Reverse strand
Band p13.1
Transcripts
ENST00000369464 ENSP00000358476
ENST00000369461 ENSP00000358473
ENST00000256649 ENSP00000256649
ENST00000497970 ENSP00000431261
ENST00000485032 ENSP00000474935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0060348 bone development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033233
View Gene Order
ENSBTAG00000001748
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301526 Hs.685191
RefSeq NM_001145635 NM_025188
HUGO
OMIM
CCDS CCDS44200 CCDS893
HPRD 15562
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca