Version 5.4
Homo sapiens Gene: HIST2H2BF
Summary
InnateDB Gene IDBG-101967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST2H2BF
Gene Name histone cluster 2, H2bf
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000203814
Encoded Proteins
IDBP-101969
histone cluster 2, H2bf
IDBP-600197
histone cluster 2, H2bf
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:149782689-149812373
Strand Reverse strand
Band q21.2
Transcripts
ENST00000369167 ENSP00000358164
ENST00000469483
ENST00000545683 ENSP00000445831
ENST00000620458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt Q5QNW6
TrEMBL
UniProt Splice Variant
Entrez Gene 440689
UniGene Hs.628485
RefSeq NM_001024599 NM_001161334 XM_006711337
HUGO HGNC:24700
OMIM
CCDS CCDS30846 CCDS53359
HPRD 18639
IMGT
EMBL AK289664 AK296916 AL591493 BC110793
GenPept AAI10794 BAF82353 BAG59471 CAI12558
RNA Seq Atlas 440689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca