Version 5.4
Homo sapiens Gene: SPRR2E
Summary
InnateDB Gene IDBG-102615.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR2E
Gene Name small proline-rich protein 2E
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000203785
Encoded Proteins
IDBP-102617
small proline-rich protein 2E
IDBP-102619
small proline-rich protein 2E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153093135-153106184
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368751 ENSP00000357740
ENST00000368750 ENSP00000357739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0008544 epidermis development
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P22531
TrEMBL
UniProt Splice Variant
Entrez Gene 6704
UniGene
RefSeq NM_001024209
HUGO HGNC:11265
OMIM
CCDS CCDS30866
HPRD
IMGT
EMBL AF333955 AL139417 M20030
GenPept AAA36639 AAK70942 CAI21953
RNA Seq Atlas 6704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca