InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRNB2

Summary

InnateDB Gene

IDBG-102965.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNB2

Gene Name

cholinergic receptor, nicotinic, beta 2 (neuronal)

Synonyms

EFNL3; nAChRB2

Species

Homo sapiens

Ensembl Gene

ENSG00000160716

Encoded Proteins

IDBP-102967

cholinergic receptor, nicotinic, beta 2 (neuronal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:154567781-154580026

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000368476

ENSP00000357461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015276	ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001508	action potential
GO:0001661	conditioned taste aversion
GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0014059	regulation of dopamine secretion
GO:0019233	sensory perception of pain
GO:0021562	vestibulocochlear nerve development
GO:0021631	optic nerve morphogenesis
GO:0021771	lateral geniculate nucleus development
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021955	central nervous system neuron axonogenesis
GO:0030890	positive regulation of B cell proliferation
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0033603	positive regulation of dopamine secretion
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0035176	social behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042113	B cell activation
GO:0042220	response to cocaine
GO:0042320	regulation of circadian sleep/wake cycle, REM sleep
GO:0042391	regulation of membrane potential
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045471	response to ethanol
GO:0045759	negative regulation of action potential
GO:0048814	regulation of dendrite morphogenesis
GO:0050877	neurological system process
GO:0050890	cognition
GO:0051291	protein heterooligomerization
GO:0051899	membrane depolarization
GO:0051963	regulation of synapse assembly
GO:0060084	synaptic transmission involved in micturition

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane