Version 5.4
Homo sapiens Gene: FLAD1
Summary
InnateDB Gene IDBG-103029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLAD1
Gene Name FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160688
Encoded Proteins
IDBP-103031
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103035
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103037
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103039
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103041
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103043
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
IDBP-103045
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154983338-154993111
Strand Forward strand
Band q21.3
Transcripts
ENST00000292180 ENSP00000292180
ENST00000368433 ENSP00000357418
ENST00000315144 ENSP00000317296
ENST00000368432 ENSP00000357417
ENST00000368431 ENSP00000357416
ENST00000295530 ENSP00000295530
ENST00000368428 ENSP00000357413
ENST00000492620
ENST00000487371
ENST00000489992
ENST00000477609
ENST00000481758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003919 FMN adenylyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006747 FAD biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006771 riboflavin metabolic process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042642
View Gene Order
ENSBTAG00000000186
Not yet available
Pathways
NETPATH
REACTOME
REACT_11070
Vitamin B2 (riboflavin) metabolism pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00740
Riboflavin metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q8NFF5
TrEMBL
UniProt Splice Variant
Entrez Gene 80308
UniGene Hs.118666
RefSeq NM_001184892 NM_001184891 NM_025207 NM_201398 XM_005245502 XM_005245503 XM_006711559
HUGO HGNC:24671
OMIM 610595
CCDS CCDS53372 CCDS1078 CCDS1079 CCDS53371
HPRD 17887
IMGT
EMBL AF218022 AF481877 AF520568 AL451085 BC011378 BC014012 BC020253 BC021096 BC032323 CH471121 DQ458779 U79241
GenPept AAB50199 AAG17264 AAH11378 AAH14012 AAH20253 AAH21096 AAH32323 AAM77338 AAO49318 ABE65383 CAI13259 CAI13260 CAI13261 CAI13262 EAW53154 EAW53155 EAW53158 EAW53159
RNA Seq Atlas 80308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca