Homo sapiens Gene: EFNA3
Summary
InnateDB Gene IDBG-103094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNA3
Gene Name ephrin-A3
Synonyms EFL2; Ehk1-L; EPLG3; LERK3
Species Homo sapiens
Ensembl Gene ENSG00000143590
Encoded Proteins
ephrin-A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155078872-155087538
Strand Forward strand
Band q21.3
Transcripts
ENST00000368408 ENSP00000357393
ENST00000470294
ENST00000498667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005005 transmembrane-ephrin receptor activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
EPHA-mediated growth cone collapse pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516656
RefSeq NM_004952
HUGO
OMIM
CCDS CCDS1090
HPRD 03225
IMGT
EMBL
GenPept
RNA Seq Atlas