InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EFNA1

Summary

InnateDB Gene

IDBG-103097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA1

Gene Name

ephrin-A1

Synonyms

B61; ECKLG; EFL1; EPLG1; LERK-1; LERK1; TNFAIP4

Species

Homo sapiens

Ensembl Gene

ENSG00000169242

Encoded Proteins

IDBP-103099

ephrin-A1

IDBP-103101

ephrin-A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:155127460-155134857

Strand

Forward strand

Band

q22

Transcripts

ENST00000368407	ENSP00000357392
ENST00000368406	ENSP00000357391
ENST00000469878
ENST00000474413
ENST00000497282

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0003180	aortic valve morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0014028	notochord formation
GO:0016477	cell migration
GO:0030182	neuron differentiation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0048013	ephrin receptor signaling pathway
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770	regulation of axonogenesis
GO:0061002	negative regulation of dendritic spine morphogenesis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome