Version 5.4
Homo sapiens Gene: CRP
Summary
InnateDB Gene IDBG-103911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRP
Gene Name C-reactive protein, pentraxin-related
Synonyms PTX1
Species Homo sapiens
Ensembl Gene ENSG00000132693
Encoded Proteins
IDBP-103913
C-reactive protein, pentraxin-related
IDBP-103915
C-reactive protein, pentraxin-related
IDBP-103917
C-reactive protein, pentraxin-related
IDBP-103919
C-reactive protein, pentraxin-related
IDBP-389209
C-reactive protein, pentraxin-related
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16751408
The major acute phase protein in humans that interacts with CFH of the alternative pathway of complement and C4BP of the classical complement pathway, limiting excessive complement activation
PMID 21383176
CRP induces FCAR surface expression, phagocytosis, and TNF secretion in neutrophils. In addition, CRP physically interacts with FCAR, and induces ERK phosphorylation, cytokine production, and degranulation in mast cells.
PMID 21415385
CRP promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, CRP treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype.
InnateDB Annotation from Orthologs
Summary
PMID 21415385
[Mus musculus] Crp promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, Crp treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype. (Demonstrated in human)
Entrez Gene
Summary The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:159712289-159714589
Strand Reverse strand
Band q23.2
Transcripts
ENST00000255030 ENSP00000255030
ENST00000368112 ENSP00000357093
ENST00000368111 ENSP00000357092
ENST00000368110 ENSP00000357091
ENST00000437342 ENSP00000402788
ENST00000473196
ENST00000489317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 21 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0030169 low-density lipoprotein particle binding
GO:0033265 choline binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006958 complement activation, classical pathway
GO:0007568 aging
GO:0008228 opsonization
GO:0010288 response to lead ion
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0042060 wound healing
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0050830 defense response to Gram-positive bacterium
GO:0051258 protein polymerization
GO:0071277 cellular response to calcium ion
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030175 filopodium
GO:0030426 growth cone
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037942
View Gene Order
ENSBTAG00000013907
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_7956
Classical antibody-mediated complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_6802
Innate Immune System pathway
REACT_8012
Creation of C4 and C2 activators pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
INOH
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.709456 Hs.76452
RefSeq NM_000567
HUGO
OMIM
CCDS CCDS30911
HPRD 00422
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca