Version 5.4
Homo sapiens Gene: VANGL2
Summary
InnateDB Gene IDBG-104048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VANGL2
Gene Name vang-like 2 (van gogh, Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162738
Encoded Proteins
IDBP-104050
vang-like 2 (van gogh, Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160400586-160428678
Strand Forward strand
Band q23.2
Transcripts
ENST00000368061 ENSP00000357040
ENST00000483408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001736 establishment of planar polarity
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0001947 heart looping
GO:0003149 membranous septum morphogenesis
GO:0003150 muscular septum morphogenesis
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0007266 Rho protein signal transduction
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0022007 convergent extension involved in neural plate elongation
GO:0030111 regulation of Wnt signaling pathway
GO:0032835 glomerulus development
GO:0032956 regulation of actin cytoskeleton organization
GO:0035019 somatic stem cell maintenance
GO:0035058 nonmotile primary cilium assembly
GO:0035567 non-canonical Wnt signaling pathway
GO:0035787 cell migration involved in kidney development
GO:0036342 post-anal tail morphogenesis
GO:0042060 wound healing
GO:0043507 positive regulation of JUN kinase activity
GO:0045176 apical protein localization
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0048103 somatic stem cell division
GO:0048105 establishment of body hair planar orientation
GO:0048546 digestive tract morphogenesis
GO:0060028 convergent extension involved in axis elongation
GO:0060029 convergent extension involved in organogenesis
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060119 inner ear receptor cell development
GO:0060122 inner ear receptor stereocilium organization
GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490 lateral sprouting involved in lung morphogenesis
GO:0060993 kidney morphogenesis
GO:0061346 planar cell polarity pathway involved in heart morphogenesis
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090175 regulation of establishment of planar polarity
GO:0090177 establishment of planar polarity involved in neural tube closure
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0001725 stress fiber
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030134 ER to Golgi transport vesicle
GO:0060187 cell pole
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026556
View Gene Order
ENSBTAG00000006560
Not yet available
Pathways
NETPATH
REACTOME
REACT_172581
PCP/CE pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.704145 Hs.99477
RefSeq NM_020335 XM_005245357
HUGO
OMIM
CCDS CCDS30915
HPRD 02758
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca