Homo sapiens Gene: MRPS14
Summary
InnateDB Gene IDBG-104966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS14
Gene Name mitochondrial ribosomal protein S14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120333
Encoded Proteins
mitochondrial ribosomal protein S14
mitochondrial ribosomal protein S14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:175010789-175023425
Strand Reverse strand
Band q25.1
Transcripts
ENST00000367677 ENSP00000431220
ENST00000498253
ENST00000476371 ENSP00000420714
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt O60783
TrEMBL F2Z361 Q96Q61
UniProt Splice Variant
Entrez Gene 63931
UniGene Hs.654858 Hs.669748
RefSeq NM_022100
HUGO HGNC:14049
OMIM 611978
CCDS CCDS1316
HPRD
IMGT
EMBL AB051350 AL049705 BC009788 Z99127 Z99297
GenPept AAH09788 BAB54940 CAB16601 CAB41269
RNA Seq Atlas 63931