Version 5.4
Homo sapiens Gene: TOR1AIP1
Summary
InnateDB Gene IDBG-105140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOR1AIP1
Gene Name torsin A interacting protein 1
Synonyms LAP1; LAP1B
Species Homo sapiens
Ensembl Gene ENSG00000143337
Encoded Proteins
IDBP-105144
torsin A interacting protein 1
IDBP-389776
torsin A interacting protein 1
IDBP-389777
torsin A interacting protein 1
IDBP-595207
torsin A interacting protein 1
IDBP-583288
torsin A interacting protein 1
IDBP-584695
torsin A interacting protein 1
IDBP-602502
torsin A interacting protein 1
IDBP-809521
torsin A interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type 2 integral membrane protein that binds A- and B-type laminins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:179882042-179925000
Strand Forward strand
Band q25.2
Transcripts
ENST00000271583 ENSP00000271583
ENST00000435319 ENSP00000393292
ENST00000447964 ENSP00000393613
ENST00000474875
ENST00000528443 ENSP00000435365
ENST00000531630 ENSP00000434316
ENST00000527391 ENSP00000432717
ENST00000529091 ENSP00000433759
ENST00000527867
ENST00000531726
ENST00000524653
ENST00000606911 ENSP00000476687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0005521 lamin binding
GO:0008092 cytoskeletal protein binding
GO:0051117 ATPase binding
Biological Process
GO:0032781 positive regulation of ATPase activity
GO:0034504 protein localization to nucleus
GO:0071763 nuclear membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026466
View Gene Order
ENSBTAG00000035226
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496459
RefSeq NM_001267578 NM_015602
HUGO
OMIM
CCDS CCDS1335 CCDS65737
HPRD 13958
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca