InnateDB: Systems Biology of the Innate Immune Response

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:45587123-45615999

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000220531	ENSP00000220531
ENST00000568597	ENSP00000454638
ENST00000566801	ENSP00000454715
ENST00000564765	ENSP00000454537
ENST00000564310	ENSP00000455439
ENST00000565409	ENSP00000455599
ENST00000568816	ENSP00000455021
ENST00000567740
ENST00000566184
ENST00000565216	ENSP00000456067
ENST00000566753	ENSP00000457478
ENST00000563000
ENST00000568963	ENSP00000454438
ENST00000567523	ENSP00000456624
ENST00000563160
ENST00000565727
ENST00000565323	ENSP00000456851
ENST00000567461	ENSP00000456152
ENST00000562384	ENSP00000457077
ENST00000569076	ENSP00000454803

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006892	post-Golgi vesicle-mediated transport
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0030318	melanocyte differentiation
GO:0031175	neuron projection development
GO:0032402	melanosome transport
GO:0032438	melanosome organization
GO:0032816	positive regulation of natural killer cell activation
GO:0033299	secretion of lysosomal enzymes
GO:0035646	endosome to melanosome transport
GO:0043473	pigmentation
GO:0048490	anterograde synaptic vesicle transport
GO:0050942	positive regulation of pigment cell differentiation
GO:0061024	membrane organization
GO:0061025	membrane fusion

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0019898	extrinsic component of membrane
GO:0030133	transport vesicle
GO:0031083	BLOC-1 complex
GO:0031201	SNARE complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005804

View Gene Order

ENSBTAG00000012250

Not yet available

Pathways

NETPATH

REACTOME

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H3BML5

UniProt Splice Variant

Entrez Gene

26258

UniGene

Hs.616277 Hs.7037 Hs.743611

RefSeq

NM_012388

HUGO

HGNC:8549

OMIM

604310

CCDS

CCDS10126

HPRD

16055

IMGT

EMBL

AC090527

GenPept

RNA Seq Atlas

26258