InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TPR

Summary

InnateDB Gene

IDBG-105409.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPR

Gene Name

translocated promoter region, nuclear basket protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000047410

Encoded Proteins

IDBP-105411

translocated promoter region (to activated MET oncogene)

IDBP-389813

translocated promoter region (to activated MET oncogene)

IDBP-813642

translocated promoter region, nuclear basket protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5\' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:186311652-186375693

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000367478	ENSP00000356448
ENST00000451586	ENSP00000408103
ENST00000467810
ENST00000492973
ENST00000481347
ENST00000491783
ENST00000469463
ENST00000474852
ENST00000613151	ENSP00000483425

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	75 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003682	chromatin binding
GO:0003729	mRNA binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0031072	heat shock protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070840	dynein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000189	MAPK import into nucleus
GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006404	RNA import into nucleus
GO:0006405	RNA export from nucleus
GO:0006606	protein import into nucleus
GO:0006999	nuclear pore organization
GO:0007067	mitotic nuclear division
GO:0007077	mitotic nuclear envelope disassembly
GO:0007094	mitotic spindle assembly checkpoint
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0010965	regulation of mitotic sister chromatid separation
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0031453	positive regulation of heterochromatin assembly
GO:0031990	mRNA export from nucleus in response to heat stress
GO:0034605	cellular response to heat
GO:0035457	cellular response to interferon-alpha
GO:0042307	positive regulation of protein import into nucleus
GO:0044281	small molecule metabolic process
GO:0045947	negative regulation of translational initiation
GO:0046827	positive regulation of protein export from nucleus
GO:0046832	negative regulation of RNA export from nucleus
GO:0055085	transmembrane transport
GO:0070849	response to epidermal growth factor
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090316	positive regulation of intracellular protein transport
GO:1901673	regulation of spindle assembly involved in mitosis

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005868	cytoplasmic dynein complex
GO:0019898	extrinsic component of membrane
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket
GO:0072686	mitotic spindle