Version 5.4
Homo sapiens Gene: LAX1
Summary
InnateDB Gene IDBG-105972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAX1
Gene Name lymphocyte transmembrane adaptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122188
Encoded Proteins
IDBP-105974
lymphocyte transmembrane adaptor 1
IDBP-389915
lymphocyte transmembrane adaptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203765176-203776233
Strand Forward strand
Band q32.1
Transcripts
ENST00000367217 ENSP00000356186
ENST00000367215
ENST00000442561 ENSP00000406970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006955 immune response
GO:0035556 intracellular signal transduction
GO:0042113 B cell activation
GO:0046649 lymphocyte activation
GO:0048305 immunoglobulin secretion
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051998
View Gene Order
ENSBTAG00000012349
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272794
RefSeq NM_001136190 NM_017773 XM_006711397 XM_006711398
HUGO
OMIM
CCDS CCDS1441 CCDS44297
HPRD 08312
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca