Version 5.4
Homo sapiens Gene: LRRN2
Summary
InnateDB Gene IDBG-106065.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRN2
Gene Name leucine rich repeat neuronal 2
Synonyms FIGLER7; GAC1; LRANK1; LRRN5
Species Homo sapiens
Ensembl Gene ENSG00000170382
Encoded Proteins
IDBP-106067
leucine rich repeat neuronal 2
IDBP-106069
leucine rich repeat neuronal 2
IDBP-106071
leucine rich repeat neuronal 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:204617170-204685733
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367177 ENSP00000356145
ENST00000367176 ENSP00000356144
ENST00000367175 ENSP00000356143
ENST00000496057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000026443
View Gene Order
Cross-References
SwissProt O75325
TrEMBL A0A024R993 B3KM66
UniProt Splice Variant
Entrez Gene 10446
UniGene Hs.26312
RefSeq NM_006338 NM_201630 XM_005244827 XM_006711115 XM_006711116
HUGO HGNC:16914
OMIM 605492
CCDS CCDS1448
HPRD
IMGT
EMBL AF030435 AK001246 AK312408 AL512306 AY358290 BC034047 BC068541 CH471067
GenPept AAC39792 AAH34047 AAH68541 AAQ88657 BAG35321 BAG50878 CAI14096 EAW91520 EAW91521 EAW91522
RNA Seq Atlas 10446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca