Version 5.4
Homo sapiens Gene: TGFB2
Summary
InnateDB Gene IDBG-106710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB2
Gene Name transforming growth factor, beta 2
Synonyms LDS4; TGF-beta2
Species Homo sapiens
Ensembl Gene ENSG00000092969
Encoded Proteins
IDBP-106712
transforming growth factor, beta 2
IDBP-106714
transforming growth factor, beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters\' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:218346235-218444619
Strand Forward strand
Band q41
Transcripts
ENST00000366929 ENSP00000355896
ENST00000366930 ENSP00000355897
ENST00000488793
ENST00000479322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005102 receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001837 epithelial to mesenchymal transition
GO:0001942 hair follicle development
GO:0001974 blood vessel remodeling
GO:0002576 platelet degranulation
GO:0003007 heart morphogenesis
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008219 cell death
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008347 glial cell migration
GO:0009611 response to wounding
GO:0009790 embryo development
GO:0010002 cardioblast differentiation
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010936 negative regulation of macrophage cytokine production
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049 cell growth
GO:0016477 cell migration
GO:0022601 menstrual cycle phase
GO:0023014 signal transduction by phosphorylation
GO:0030097 hemopoiesis
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030593 neutrophil chemotaxis
GO:0031069 hair follicle morphogenesis
GO:0032147 activation of protein kinase activity
GO:0032570 response to progesterone
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032909 regulation of transforming growth factor beta2 production
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0040007 growth
GO:0042060 wound healing
GO:0042416 dopamine biosynthetic process
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042637 catagen
GO:0042981 regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045216 cell-cell junction organization
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045778 positive regulation of ossification
GO:0045787 positive regulation of cell cycle
GO:0045823 positive regulation of heart contraction
GO:0048103 somatic stem cell division
GO:0048566 embryonic digestive tract development
GO:0048663 neuron fate commitment
GO:0048666 neuron development
GO:0048699 generation of neurons
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050777 negative regulation of immune response
GO:0050778 positive regulation of immune response
GO:0051781 positive regulation of cell division
GO:0051795 positive regulation of catagen
GO:0051891 positive regulation of cardioblast differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060325 face morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0070237 positive regulation of activation-induced cell death of T cells
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0030424 axon
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039239
View Gene Order
ENSBTAG00000005359
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163906
ECM proteoglycans pathway
REACT_604
Hemostasis pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04144
Endocytosis pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05140
Leishmaniasis pathway
hsa05146
Amoebiasis pathway
hsa05144
Malaria pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
atf2_pathway
ATF-2 transcription factor network
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133379 Hs.595065 Hs.726819
RefSeq NM_001135599 NM_003238
HUGO
OMIM
CCDS CCDS1521 CCDS44318
HPRD 01828
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca