Homo sapiens Gene: SLC30A10

Summary
InnateDB Gene IDBG-106720.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SLC30A10
Gene Name solute carrier family 30, member 10
Synonyms HMDPC; ZnT-10; ZNT10; ZNT8; ZRC1
Species Homo sapiens
Ensembl Gene ENSG00000196660
Encoded Proteins
IDBP-106722 solute carrier family 30, member 10
IDBP-106724 solute carrier family 30, member 10
IDBP-585746 solute carrier family 30, member 10
IDBP-587135 solute carrier family 30, member 10
Entrez Gene
Summary This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 219858769-220131989
Strand Reverse strand
Band q41
Transcripts
ENST00000356609  ENSP00000349018
ENST00000366926  ENSP00000355893
ENST00000484239 
ENST00000484079 
ENST00000536446  ENSP00000439489
ENST00000536992  ENSP00000440627
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0008324 cation transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0006829 zinc ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000026614 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000004414 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6XR72 
TrEMBL B3KR19
UniProt Splice Variant
Entrez Gene 55532 
UniGene Hs.284450
RefSeq NM_018713 
HUGO 25355 
OMIM 611146
CCDS CCDS31026 
HPRD 15367
IMGT
EMBL AC093562 AK090806 AL359609 AY212919 BC036078 CH471100
GenPept AAH36078  AAP44332  BAG52231  CAB94880  EAW93312  EAW93314 
ImmGen SLC30A10 (murine) 
RNA Seq Atlas 55532