InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUP133

Summary

InnateDB Gene

IDBG-107322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP133

Gene Name

nucleoporin 133kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000069248

Encoded Proteins

IDBP-107324

nucleoporin 133kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:229440260-229508341

Strand

Reverse strand

Band

q42.13

Transcripts

ENST00000261396	ENSP00000261396
ENST00000366678
ENST00000490352
ENST00000485119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0006999	nuclear pore organization
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0048339	paraxial mesoderm development
GO:0055085	transmembrane transport

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0000940	condensed chromosome outer kinetochore
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005829	cytosol
GO:0016020	membrane
GO:0031080	nuclear pore outer ring