Homo sapiens Gene: AGT
Summary
InnateDB Gene IDBG-107363.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol AGT
Gene Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Synonyms ANHU; SERPINA8;
Species Homo sapiens
Ensembl Gene ENSG00000135744
Encoded Proteins
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Protein Structure
Entrez Gene
Summary The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:230838269-230850043
Strand Reverse strand
Band q42.2
Transcripts
ENST00000366667 ENSP00000355627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005179 hormone activity
GO:0008083 growth factor activity
GO:0010698 acetyltransferase activator activity
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031703 type 2 angiotensin receptor binding
Biological Process
GO:0001543 ovarian follicle rupture
GO:0001558 regulation of cell growth
GO:0001568 blood vessel development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001974 blood vessel remodeling
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002019 regulation of renal output by angiotensin
GO:0002034 regulation of blood vessel size by renin-angiotensin
GO:0002035 brain renin-angiotensin system
GO:0003051 angiotensin-mediated drinking behavior
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006883 cellular sodium ion homeostasis
GO:0006917 induction of apoptosis
GO:0007160 cell-matrix adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007263 nitric oxide mediated signal transduction
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0007588 excretion
GO:0008065 establishment of blood-nerve barrier
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009651 response to salt stress
GO:0010468 regulation of gene expression
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010873 positive regulation of cholesterol esterification
GO:0010951 negative regulation of endopeptidase activity
GO:0014061 regulation of norepinephrine secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014824 artery smooth muscle contraction
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0019229 regulation of vasoconstriction
GO:0030162 regulation of proteolysis
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0030432 peristalsis
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034104 negative regulation of tissue remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0035411 catenin import into nucleus
GO:0035813 regulation of renal sodium excretion
GO:0035815 positive regulation of renal sodium excretion
GO:0040018 positive regulation of multicellular organism growth
GO:0042127 regulation of cell proliferation
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0042445 hormone metabolic process
GO:0042756 drinking behavior
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045777 positive regulation of blood pressure
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0046622 positive regulation of organ growth
GO:0048143 astrocyte activation
GO:0048144 fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048659 smooth muscle cell proliferation
GO:0050663 cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051387 negative regulation of nerve growth factor receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051924 regulation of calcium ion transport
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070371 ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0044444 cytoplasmic part
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Peptide ligand-binding receptors pathway
Metabolism of Angiotensinogen to Angiotensins pathway
PPARA Activates Gene Expression pathway
KEGG
Renin-angiotensin system pathway
Vascular smooth muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
G-protein signaling through tubby proteins [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
AP-1 transcription factor network
Signaling events mediated by PRL
Cross-References
SwissProt P01019
TrEMBL B0ZBE2
UniProt Splice Variant
Entrez Gene 183
UniGene Hs.19383
RefSeq NM_000029
HUGO 333
OMIM 106150
CCDS CCDS1585
HPRD 00106
IMGT
EMBL AL158214 AL512328 BC011519 CH471098 EU326304 K02215 M24686 M24687 M24688 M24689 M69110 S78529 S78530 X15324 X15325 X15326 X15327
GenPept AAA51679 AAA51731 AAA52282 AAD14287 AAD14288 AAH11519 ACA05910 CAA33385 CAI15356 EAW69918
ImmGen AGT (murine)
RNA Seq Atlas 183