InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AGT

Summary

InnateDB Gene

IDBG-107363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGT

Gene Name

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Synonyms

ANHU; SERPINA8

Species

Homo sapiens

Ensembl Gene

ENSG00000135744

Encoded Proteins

IDBP-107365

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:230702523-230714297

Strand

Reverse strand

Band

q42.2

Transcripts

ENST00000366667

ENSP00000355627

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	21 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0031701	angiotensin receptor binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031703	type 2 angiotensin receptor binding

Biological Process

GO:0001543	ovarian follicle rupture
GO:0001558	regulation of cell growth
GO:0001568	blood vessel development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001819	positive regulation of cytokine production
GO:0001822	kidney development
GO:0001974	blood vessel remodeling
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002003	angiotensin maturation
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002019	regulation of renal output by angiotensin
GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0002035	brain renin-angiotensin system
GO:0003014	renal system process
GO:0003051	angiotensin-mediated drinking behavior
GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006883	cellular sodium ion homeostasis
GO:0007160	cell-matrix adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007263	nitric oxide mediated signal transduction
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0007568	aging
GO:0007588	excretion
GO:0008065	establishment of blood-nerve barrier
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009409	response to cold
GO:0009651	response to salt stress
GO:0010468	regulation of gene expression
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0010595	positive regulation of endothelial cell migration
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010873	positive regulation of cholesterol esterification
GO:0010951	negative regulation of endopeptidase activity
GO:0014061	regulation of norepinephrine secretion
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014824	artery smooth muscle contraction
GO:0014873	response to muscle activity involved in regulation of muscle adaptation
GO:0016525	negative regulation of angiogenesis
GO:0019229	regulation of vasoconstriction
GO:0030162	regulation of proteolysis
GO:0030198	extracellular matrix organization
GO:0030308	negative regulation of cell growth
GO:0030432	peristalsis
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032930	positive regulation of superoxide anion generation
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0034104	negative regulation of tissue remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0035411	catenin import into nucleus
GO:0035813	regulation of renal sodium excretion
GO:0035815	positive regulation of renal sodium excretion
GO:0040018	positive regulation of multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0042445	hormone metabolic process
GO:0042756	drinking behavior
GO:0042981	regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045777	positive regulation of blood pressure
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0046622	positive regulation of organ growth
GO:0048143	astrocyte activation
GO:0048144	fibroblast proliferation
GO:0048146	positive regulation of fibroblast proliferation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048659	smooth muscle cell proliferation
GO:0050663	cytokine secretion
GO:0050727	regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051145	smooth muscle cell differentiation
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051403	stress-activated MAPK cascade
GO:0051924	regulation of calcium ion transport
GO:0051969	regulation of transmission of nerve impulse
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070371	ERK1 and ERK2 cascade
GO:0070471	uterine smooth muscle contraction
GO:0071260	cellular response to mechanical stimulus
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway