Version 5.4
Homo sapiens Gene: MLK4
Summary
InnateDB Gene IDBG-107484.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLK4
Gene Name Mitogen-activated protein kinase kinase kinase MLK4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143674
Encoded Proteins
IDBP-107486
Mitogen-activated protein kinase kinase kinase MLK4
IDBP-107488
Mitogen-activated protein kinase kinase kinase MLK4
IDBP-107490
Mitogen-activated protein kinase kinase kinase MLK4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:233327768-233385148
Strand Forward strand
Band q42.2
Transcripts
ENST00000366624 ENSP00000355583
ENST00000366623 ENSP00000355582
ENST00000366622 ENSP00000355581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007257 activation of JUN kinase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031853
View Gene Order
ENSBTAG00000021183
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.547779 Hs.617078
RefSeq NM_032435
HUGO
OMIM
CCDS CCDS1598
HPRD 10087
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca