Version 5.4
Homo sapiens Gene: GNG4
Summary
InnateDB Gene IDBG-107558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG4
Gene Name guanine nucleotide binding protein (G protein), gamma 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168243
Encoded Proteins
IDBP-107560
guanine nucleotide binding protein (G protein), gamma 4
IDBP-107562
guanine nucleotide binding protein (G protein), gamma 4
IDBP-246851
guanine nucleotide binding protein (G protein), gamma 4
IDBP-390158
guanine nucleotide binding protein (G protein), gamma 4
IDBP-807413
guanine nucleotide binding protein (G protein), gamma 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:235547687-235650754
Strand Reverse strand
Band q42.3
Transcripts
ENST00000366598 ENSP00000355557
ENST00000366597 ENSP00000355556
ENST00000391854 ENSP00000375727
ENST00000450593 ENSP00000398629
ENST00000484517 ENSP00000482192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0030308 negative regulation of cell growth
GO:0044281 small molecule metabolic process
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021303
View Gene Order
ENSBTAG00000002908
Not yet available
Pathways
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21340
GPCR ligand binding pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P50150
TrEMBL B1APZ0
UniProt Splice Variant
Entrez Gene 2786
UniGene Hs.159711
RefSeq NM_001098722 XM_006711761 XM_006711762 NM_001098721 NM_004485
HUGO HGNC:4407
OMIM 604388
CCDS CCDS1607
HPRD 11978
IMGT
EMBL AF493872 AK311781 BC022485 CH471098 U31382
GenPept AAC50204 AAH22485 AAM12586 BAG34724 EAW70030 EAW70031
RNA Seq Atlas 2786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca