Version 5.4
Homo sapiens Gene: SLC6A19
Summary
InnateDB Gene IDBG-10885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A19
Gene Name solute carrier family 6 (neutral amino acid transporter), member 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174358
Encoded Proteins
IDBP-10887
solute carrier family 6 (neutral amino acid transporter), member 19
IDBP-477644
solute carrier family 6 (neutral amino acid transporter), member 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:1201595-1225117
Strand Forward strand
Band p15.33
Transcripts
ENST00000304460 ENSP00000305302
ENST00000515652 ENSP00000425701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005515 protein binding
GO:0015175 neutral amino acid transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0007584 response to nutrient
GO:0015804 neutral amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021565
View Gene Order
ENSBTAG00000045695
Not yet available
Pathways
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q695T7
TrEMBL B3KVZ8 E9PD72
UniProt Splice Variant
Entrez Gene 340024
UniGene Hs.481478
RefSeq NM_001003841
HUGO HGNC:27960
OMIM 608893
CCDS CCDS34130
HPRD
IMGT
EMBL AC114291 AK123779 AK290811 AY591756 AY596807 CH471102
GenPept AAT42127 AAT66171 BAF83500 BAG53960 EAX08175
RNA Seq Atlas 340024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca