Version 5.4
Homo sapiens Gene: CEP152
Summary
InnateDB Gene IDBG-11247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP152
Gene Name centrosomal protein 152kDa
Synonyms MCPH4; MCPH9; SCKL5
Species Homo sapiens
Ensembl Gene ENSG00000103995
Encoded Proteins
IDBP-11249
centrosomal protein 152kDa
IDBP-11251
centrosomal protein 152kDa
IDBP-230837
centrosomal protein 152kDa
IDBP-584749
centrosomal protein 152kDa
IDBP-598613
centrosomal protein 152kDa
IDBP-584729
centrosomal protein 152kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:48712928-48811146
Strand Reverse strand
Band q21.1
Transcripts
ENST00000380950 ENSP00000370337
ENST00000325747 ENSP00000321000
ENST00000399334 ENSP00000382271
ENST00000561245 ENSP00000453591
ENST00000559398
ENST00000560322 ENSP00000453440
ENST00000558337
ENST00000559444
ENST00000558591 ENSP00000453914
ENST00000559630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007099 centriole replication
GO:0030030 cell projection organization
GO:0051298 centrosome duplication
GO:0098535 de novo centriole assembly
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0098536 deuterosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068394
View Gene Order
ENSBTAG00000011661
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YMG1
UniProt Splice Variant
Entrez Gene 22995
UniGene Hs.597323 Hs.734263
RefSeq NM_001194998 NM_014985 XM_006720437
HUGO HGNC:29298
OMIM 613529
CCDS CCDS42033 CCDS58361
HPRD 16778
IMGT
EMBL AC012379 AC022084 AC084757
GenPept
RNA Seq Atlas 22995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca