Version 5.4
Homo sapiens Gene: USP18
Summary
InnateDB Gene IDBG-1145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP18
Gene Name ubiquitin specific peptidase 18
Synonyms ISG43; UBP43
Species Homo sapiens
Ensembl Gene ENSG00000184979
Encoded Proteins
IDBP-1147
ubiquitin specific peptidase 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:18149899-18177397
Strand Forward strand
Band q11.21
Transcripts
ENST00000215794 ENSP00000215794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030107
View Gene Order
ENSBTAG00000016661
Not yet available
Pathways
NETPATH
REACTOME
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UMW8
TrEMBL
UniProt Splice Variant
Entrez Gene 11274
UniGene Hs.38260 Hs.474184 Hs.585279 Hs.637428 Hs.736485
RefSeq NM_017414
HUGO HGNC:12616
OMIM 607057
CCDS CCDS13752
HPRD
IMGT
EMBL AF176642 AJ243526 AK313385 AL136690 BC014896 BT006835 CR457216 CT841507
GenPept AAD49967 AAH14896 AAP35481 BAG36183 CAB66625 CAB76398 CAG33497 CAJ86437
RNA Seq Atlas 11274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca