Version 5.4
Homo sapiens Gene: FBLN1
Summary
InnateDB Gene IDBG-11494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBLN1
Gene Name fibulin 1
Synonyms FBLN; FIBL1
Species Homo sapiens
Ensembl Gene ENSG00000077942
Encoded Proteins
IDBP-11496
fibulin 1
IDBP-11500
fibulin 1
IDBP-11502
fibulin 1
IDBP-295651
fibulin 1
IDBP-379894
fibulin 1
IDBP-379898
fibulin 1
IDBP-379900
fibulin 1
IDBP-379932
fibulin 1
IDBP-379936
fibulin 1
IDBP-379937
fibulin 1
IDBP-379939
fibulin 1
IDBP-379943
fibulin 1
IDBP-379945
fibulin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3\' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:45502238-45601135
Strand Forward strand
Band q13.31
Transcripts
ENST00000327858 ENSP00000331544
ENST00000340923 ENSP00000342212
ENST00000262722 ENSP00000262722
ENST00000402984 ENSP00000385521
ENST00000411478 ENSP00000415289
ENST00000445110 ENSP00000404024
ENST00000455233 ENSP00000402963
ENST00000442170 ENSP00000393812
ENST00000439835 ENSP00000395329
ENST00000450975 ENSP00000396084
ENST00000454279 ENSP00000414584
ENST00000451475 ENSP00000415160
ENST00000437711 ENSP00000401077
ENST00000460538
ENST00000465578
ENST00000484531
ENST00000476366
ENST00000460300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016504 peptidase activator activity
Biological Process
GO:0007566 embryo implantation
GO:0010952 positive regulation of peptidase activity
GO:0016032 viral process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006369
View Gene Order
ENSBTAG00000012088
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593123
RefSeq NM_001996 NM_006485 NM_006486 NM_006487
HUGO
OMIM
CCDS CCDS14067 CCDS14068 CCDS14069 CCDS43028
HPRD 00629
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca