InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPM7

Summary

InnateDB Gene

IDBG-11807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM7

Gene Name

transient receptor potential cation channel, subfamily M, member 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000092439

Encoded Proteins

IDBP-11809

transient receptor potential cation channel, subfamily M, member 7

IDBP-593310

transient receptor potential cation channel, subfamily M, member 7

IDBP-586572

transient receptor potential cation channel, subfamily M, member 7

IDBP-600937

transient receptor potential cation channel, subfamily M, member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:50552473-50686815

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000313478	ENSP00000320239
ENST00000561267	ENSP00000454066
ENST00000560955	ENSP00000453277
ENST00000561443
ENST00000560516
ENST00000558444
ENST00000560849
ENST00000560284
ENST00000560638	ENSP00000452873

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004674	protein serine/threonine kinase activity
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017022	myosin binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0016340	calcium-dependent cell-matrix adhesion
GO:0031032	actomyosin structure organization
GO:0034220	ion transmembrane transport
GO:0046777	protein autophosphorylation
GO:0055085	transmembrane transport
GO:0070266	necroptotic process
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0001726	ruffle
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027365

View Gene Order

ENSBTAG00000031165

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.512894 Hs.734904

RefSeq

NM_001301212 NM_017672 XM_005254488 XM_006720582

HUGO

OMIM

CCDS

CCDS42035 CCDS73725

HPRD

10418

IMGT

EMBL

GenPept

RNA Seq Atlas