Version 5.4
Homo sapiens Gene: SOD3
Summary
InnateDB Gene IDBG-11874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOD3
Gene Name superoxide dismutase 3, extracellular
Synonyms EC-SOD
Species Homo sapiens
Ensembl Gene ENSG00000109610
Encoded Proteins
IDBP-11878
superoxide dismutase 3, extracellular
IDBP-712719
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:24789912-24800842
Strand Forward strand
Band p15.2
Transcripts
ENST00000382120 ENSP00000371554
ENST00000598411 ENSP00000472134
ENST00000593742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0019430 removal of superoxide radicals
GO:0046688 response to copper ion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000072941
View Gene Order
ENSBTAG00000013980
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P08294
TrEMBL M0R1V4
UniProt Splice Variant
Entrez Gene 6649
UniGene Hs.628252
RefSeq NM_003102
HUGO HGNC:11181
OMIM 185490
CCDS CCDS3430
HPRD
IMGT
EMBL AC006390 AY787834 BC014418 CR541853 J02947 U10116
GenPept AAA62278 AAA66000 AAH14418 AAV40827 CAG46651
RNA Seq Atlas 6649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca