Homo sapiens Gene: NLRC3 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Gene | IDBG-12133.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | NLRC3 | ||||||||||||||||||
Gene Name | NLR family, CARD domain containing 3 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000167984 | ||||||||||||||||||
Encoded Proteins |
NLR family, CARD domain containing 3
NLR family, CARD domain containing 3
NLR family, CARD domain containing 3
NLR family, CARD domain containing 3
NLR family, CARD domain containing 3
|
||||||||||||||||||
Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
NLRC3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor TRAF6 to attenuate ubiquitination of TRAF6 and activation of NF-kB. (Demonstrated in mouse)
|
||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Mus musculus] Nlrc3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor Traf6 to attenuate ubiquitination of Traf6 and activation of NF-kB.
|
||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a cytosolic regulator of innate immunity. The encoded protein contains several leucine-rich repeat domains and may be involved in regulating T-cell activation. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2013] |
||||||||||||||||||
Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 16:3539033-3577400 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p13.3 | ||||||||||||||||||
Transcripts |
|
||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 197358 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_178844 | ||||||||||||||||||
HUGO | HGNC:29889 | ||||||||||||||||||
OMIM | 615648 | ||||||||||||||||||
CCDS | CCDS73817 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 197358 | ||||||||||||||||||