Version 5.4
Homo sapiens Gene: ROPN1L
Summary
InnateDB Gene IDBG-12440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROPN1L
Gene Name rhophilin associated tail protein 1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145491
Encoded Proteins
IDBP-12444
rhophilin associated tail protein 1-like
IDBP-482785
rhophilin associated tail protein 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ropporin family. The encoded protein is a sperm protein. It interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helix domain of AKAP3, which allows PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10441524-10472029
Strand Forward strand
Band p15.2
Transcripts
ENST00000274134 ENSP00000274134
ENST00000503804 ENSP00000421405
ENST00000510520
ENST00000515762
ENST00000512022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement
GO:0030317 sperm motility
GO:0048240 sperm capacitation
Cellular Component
GO:0005737 cytoplasm
GO:0031514 motile cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022236
View Gene Order
ENSBTAG00000003539
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001201466 NM_031916
HUGO
OMIM
CCDS CCDS3879
HPRD 17986
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca