Homo sapiens Gene: EIF2B2

Summary
InnateDB Gene IDBG-12676.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol EIF2B2
Gene Name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Synonyms EIF-2Bbeta; EIF2B
Species Homo sapiens
Ensembl Gene ENSG00000119718
Encoded Proteins
IDBP-12678 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-595800 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-592794 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-596114 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Entrez Gene
Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14: 75469614-75476292
Strand Forward strand
Band q24.3
Transcripts
ENST00000266126  ENSP00000266126
ENST00000555522 
ENST00000553539 
ENST00000556028  ENSP00000452311
ENST00000553401  ENSP00000451681
ENST00000554748  ENSP00000452582
ENST00000556668 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein‑Protein  41
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0007417 central nervous system development
GO:0009408 response to heat
GO:0009749 response to glucose stimulus
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0042552 myelination
GO:0043434 response to peptide hormone stimulus
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000004788 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000008664 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_1815 Recycling of eIF2:GDP
KEGG
hsa03013  RNA transport
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P49770 
TrEMBL G3V5E5 H0YJJ8 H0YK01 Q53XC2
UniProt Splice Variant
Entrez Gene 8892 
UniGene Hs.409137
RefSeq NM_014239 
HUGO 3258 
OMIM 606454
CCDS CCDS9836 
HPRD 05923
IMGT
EMBL AC006530 AF035280 AL049780 BC011750 BX161473 CH471061 L40395
GenPept AAB88176  AAC42002  AAD30183  AAH11750  CAD61929  EAW81210 
ImmGen EIF2B2 (murine) 
RNA Seq Atlas 8892