Version 5.4
Homo sapiens Gene: EIF2B2
Summary
InnateDB Gene IDBG-12676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2B2
Gene Name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Synonyms EIF-2Bbeta; EIF2B
Species Homo sapiens
Ensembl Gene ENSG00000119718
Encoded Proteins
IDBP-12678
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-595800
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-592794
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
IDBP-596114
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75002911-75012366
Strand Forward strand
Band q24.3
Transcripts
ENST00000266126 ENSP00000266126
ENST00000555522
ENST00000553539
ENST00000556028 ENSP00000452311
ENST00000553401 ENSP00000451681
ENST00000554748 ENSP00000452582
ENST00000556668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0007417 central nervous system development
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0042552 myelination
GO:0043434 response to peptide hormone
GO:0043547 positive regulation of GTPase activity
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004788
View Gene Order
ENSBTAG00000008664
Not yet available
Pathways
NETPATH
REACTOME
REACT_1815
Recycling of eIF2:GDP pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409137
RefSeq NM_014239
HUGO
OMIM
CCDS CCDS9836
HPRD 05923
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca