Homo sapiens Gene: EIF2B2
Summary
InnateDB Gene IDBG-12676.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol EIF2B2
Gene Name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Synonyms EIF-2Bbeta; EIF2B;
Species Homo sapiens
Ensembl Gene ENSG00000119718
Encoded Proteins
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Protein Structure
Entrez Gene
Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75469614-75476292
Strand Forward strand
Band q24.3
Transcripts
ENST00000266126 ENSP00000266126
ENST00000555522
ENST00000553539
ENST00000556028 ENSP00000452311
ENST00000553401 ENSP00000451681
ENST00000554748 ENSP00000452582
ENST00000556668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0007417 central nervous system development
GO:0009408 response to heat
GO:0009749 response to glucose stimulus
GO:0010467 gene expression
GO:0014003 oligodendrocyte development
GO:0042552 myelination
GO:0043434 response to peptide hormone stimulus
GO:0044237 cellular metabolic process
GO:0044267 cellular protein metabolic process
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Recycling of eIF2:GDP pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P49770
TrEMBL G3V5E5 H0YJJ8 H0YK01 Q53XC2
UniProt Splice Variant
Entrez Gene 8892
UniGene Hs.409137
RefSeq NM_014239
HUGO 3258
OMIM 606454
CCDS CCDS9836
HPRD 05923
IMGT
EMBL AC006530 AF035280 AL049780 BC011750 BX161473 CH471061 L40395
GenPept AAB88176 AAC42002 AAD30183 AAH11750 CAD61929 EAW81210
ImmGen EIF2B2 (murine)
RNA Seq Atlas 8892