InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab10

Summary

InnateDB Gene

IDBG-127682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab10

Gene Name

RAB10, member RAS oncogene family

Synonyms

AW107754

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020671

Encoded Proteins

IDBP-127684

RAB10, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084733:
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:3247430-3309969

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000021001

ENSMUSP00000021001

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0031489	myosin V binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006893	Golgi to plasma membrane transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016197	endosomal transport
GO:0019882	antigen processing and presentation
GO:0030859	polarized epithelial cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0043001	Golgi to plasma membrane protein transport
GO:0045200	establishment of neuroblast polarity
GO:0061467	basolateral protein localization
GO:0071786	endoplasmic reticulum tubular network organization
GO:0072659	protein localization to plasma membrane
GO:0097051	establishment of protein localization to endoplasmic reticulum membrane

Cellular Component

GO:0000145	exocyst
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0032593	insulin-responsive compartment
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome
GO:0071782	endoplasmic reticulum tubular network
GO:0072372	primary cilium

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000084733

View Gene Order

ENSBTAG00000000985

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_199054

Translocation of GLUT4 to the plasma membrane pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.449218

RefSeq

NM_016676

OMIM

CCDS

CCDS25782

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas