InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo4

Summary

InnateDB Gene

IDBG-127886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo4

Gene Name

F-box protein 4

Synonyms

1700096C12Rik; AI851261; AW494535; Fbx4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022184

Encoded Proteins

IDBP-127888

F-box protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151876:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:3965445-3979573

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022791	ENSMUSP00000022791
ENSMUST00000148817
ENSMUST00000148169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000723	telomere maintenance
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination