Version 5.4
Mus musculus Gene: C6
Summary
InnateDB Gene IDBG-127938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6
Gene Name complement component 6
Synonyms AW111623
Species Mus musculus
Ensembl Gene ENSMUSG00000022181
Encoded Proteins
IDBP-127940
complement component 6
IDBP-539693
complement component 6
IDBP-538532
complement component 6
IDBP-542026
complement component 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11058761
[Homo sapiens] Complement component six is one of five components that interact to form the cytolytic membrane attack complex (MAC)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039537:
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:4727175-4815456
Strand Forward strand
Band A1
Transcripts
ENSMUST00000022788 ENSMUSP00000022788
ENSMUST00000162585 ENSMUSP00000124417
ENSMUST00000161997 ENSMUSP00000125358
ENSMUST00000162350 ENSMUSP00000125693
ENSMUST00000162729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001970 positive regulation of activation of membrane attack complex
GO:0006955 immune response
GO:0045766 positive regulation of angiogenesis
GO:0045917 positive regulation of complement activation
Cellular Component
GO:0005579 membrane attack complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000039537
View Gene Order
ENSBTAG00000014177
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20247
RefSeq NM_016704
OMIM
CCDS CCDS37025
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca