InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptger4

Summary

InnateDB Gene

IDBG-128023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptger4

Gene Name

prostaglandin E receptor 4 (subtype EP4)

Synonyms

EP4; Ptgerep4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039942

Encoded Proteins

IDBP-128025

prostaglandin E receptor 4 (subtype EP4)

IDBP-401776

prostaglandin E receptor 4 (subtype EP4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171522:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:5206661-5244187

Strand

Reverse strand

Band

Transcripts

ENSMUST00000047379	ENSMUSP00000048736
ENSMUST00000120563	ENSMUSP00000112858
ENSMUST00000133966

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0009612	response to mechanical stimulus
GO:0030278	regulation of ossification
GO:0032496	response to lipopolysaccharide
GO:0033624	negative regulation of integrin activation
GO:0042093	T-helper cell differentiation
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051492	regulation of stress fiber assembly
GO:0060348	bone development
GO:0070371	ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:2000420	negative regulation of eosinophil extravasation