Version 5.4
Mus musculus Gene: Fyb
Summary
InnateDB Gene IDBG-128115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fyb
Gene Name FYN binding protein
Synonyms ADAP; B630013F22Rik; FYB-120/130; p120/130; p120/p130; Slap130
Species Mus musculus
Ensembl Gene ENSMUSG00000022148
Encoded Proteins
IDBP-128117
FYN binding protein
IDBP-539488
FYN binding protein
IDBP-538203
FYN binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:6579871-6663313
Strand Forward strand
Band A1
Transcripts
ENSMUST00000090461 ENSMUSP00000087947
ENSMUST00000159714
ENSMUST00000160612 ENSMUSP00000124553
ENSMUST00000162430
ENSMUST00000163073 ENSMUSP00000123895
ENSMUST00000159604
ENSMUST00000162154
ENSMUST00000161947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000082074
View Gene Order
ENSBTAG00000001492
Not yet available
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_215628
Signal regulatory protein (SIRP) family interactions pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_223082
Cell-Cell communication pathway
REACT_222648
TCR signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_12623
Generation of second messenger molecules pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.170905
RefSeq NM_011815 XM_006519982
OMIM
CCDS CCDS37031
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca